The Fly (1986)

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The beleaguered Jeff Goldblum stars as the scientist who begins to mutate after his genes are scrambled with those of a fly during a teleportation experiment. David Cronenberg's terrific sci-fi remake of the 1958 original is fired by superb performances, especially from Goldblum, who has never been better. Geena Davis - later to become his wife - plays his understandably concerned girlfriend. Keep a sick bag handy for the disgustingly impressive effects.