Cars lie abandoned on litter-strewn city steets, locals wildly stagger around and the overstretched police are engulfed by a lawlessness they cannot contain.
But it's not just a normal Saturday night in Glasgow. No, the city is in the grip of a virus that robs victims of their senses and apparently has no cure.
Epidemologist Susan (Green) is called in when the disease first makes its presence felt - a Glaswegian lorry driver is found blubbing at the wheel...and then loses his sense of smell.
It seems the virus' onset is accompanied by a massive sense of grief when the host experiences mind-shattering feelings of sorrow and regret for wrongs they may have caused to others (so there's little chance of the Royal Bank of Scotland succumbing).
It's quickly established the affliction - known as SOS (Sensory Olfactory Syndrome) - is not contagious but is springing up in a clusters across the globe.
So it's just as well that after Susan contracts the illness she finds a tattoed shoulder to cry on when she hooks up with McGregor's shouty chef Michael.
Director David Mackenzie's refreshing take on the disaster plague genre goes for the personal rather than the pandemic - focussing on how Susan and Michael adapt to losing their senses one by one to keep their love alive.
It's a tall order when taste and hearing go the journey...but the movie's optimistic message is that we can overcome anything.